Survival analysis is a key statistical method in clinical research, used to analyze the time until an event of interest, such as death, …

Computing and approximating multivariate chi-square probabilities. The multivariate chi-squared distribution is an extension of the …

Adaptive designs are becoming increasingly important in clinical trials, reflecting a shift towards more flexible and efficient study methodologies. …

In clinical trials, one of the fundamental goals is to understand the effect of a treatment or intervention. To achieve this, we need to clearly define what exactly we are trying to measure. This is where the concept of estimands becomes crucial …

A framework in the literature for the applicability of the different methods to handle missingness is based on a classification according to the following missingness mechanisms …